da molecularpost | Giu 14, 2023 | Biologia Molecolare, Intestine, Organoids, Regeneration
Controlling intestinal organoid regeneration with retinoic acid and RXR inhibition Fig. 1 – RXR is a homing mechanism to exit regenerative state and its inhibition leads to regenerative phenotype; retinoic acid provides tissue-specificity [Created with...
da molecularpost | Giu 14, 2023 | Biologia Molecolare, Cancer, Organoids
Organoids and Tumor Immune Microenvironment: a new strategy of modelling Figure 1 – Schematic representation of ALI PDO establishment starting from human and mouse derived tumor biopsies. All those models faithfully recapitulate the TME and preserve the TCR...
da molecularpost | Giu 12, 2023 | Biologia Molecolare
Decoding the human genome: the most accurate version ever Figure 1 – The researchers succeed in adding a missing piece of the human genome, represented like a complex puzzle. Abstract Since the first version of the human genome was released, it was clear that it...
da molecularpost | Giu 3, 2023 | Biologia Molecolare, Organoids
CRISPR/Cas9 mediated repair of CFTR in cystic fibrosis patient-derived intestinal organoids Figure 1 – Schematic illustration of the gene correction protocol. Stem cells are labelled in green. Created with biorender.com Abstract Single intestinal stem cells in...
da molecularpost | Mag 29, 2023 | Biologia Molecolare, Organoids
Transplantation of intestinal organoids into murine models Figure 1. Schematic illustration of procedure through which the transplantation of intestinal organoids is performed Abstract Intestinal organoids are in vitro tools that can be transplanted in vivo. They can...
da molecularpost | Mag 28, 2023 | Biologia Molecolare, Cancer
Tornado-seq: a new method for anti-cancer drugs screening Figure 1 – Schematic representation of general idea of Tornado-seq Abstract Norkin et al. develop an organoid screening for the analysis of complex biological systems involving many cell types and alternative...