da molecularpost | Giu 14, 2023 | Biologia Molecolare, Intestine, Organoids, Regeneration
Controlling intestinal organoid regeneration with retinoic acid and RXR inhibition Fig. 1 – RXR is a homing mechanism to exit regenerative state and its inhibition leads to regenerative phenotype; retinoic acid provides tissue-specificity [Created with...
da molecularpost | Mag 20, 2023 | Biologia Molecolare, Liver, Organoids
Genetic engineering of human organoids using a homology independent CRISPR-Cas9 Figure 1 – Comparison between HDR and NHEJ mechanism. In the HDR mechanism are highlighted the homology arms (HA). Created with Biorender. Abstract Organoids are in vitro generated...
da molecularpost | Giu 15, 2021 | Biologia Molecolare, Liver, Organoids
Liver organoids: characteristics and future perspectives Abstract Liver bud organoids offer an alternative to traditional 2D cell cultures, but in order to exploit all their potential it is necessary to understand how cell communication affects differentiation. Camp...
da molecularpost | Giu 11, 2021 | Biologia Molecolare
Can human heart regenerate? A new possible strategy Figure 1 – Cardiomyocyte proliferation promoted by both a cell-cycle network and mevalonate (cholesterol) pathway activation Abstract Heart muscle does not regenerate following injury, which instead leads to heart...