da molecularpost | Giu 14, 2023 | Biologia Molecolare, Intestine, Organoids, Regeneration
Controlling intestinal organoid regeneration with retinoic acid and RXR inhibition Fig. 1 – RXR is a homing mechanism to exit regenerative state and its inhibition leads to regenerative phenotype; retinoic acid provides tissue-specificity [Created with...
da molecularpost | Giu 14, 2023 | Biologia Molecolare, Cancer, Organoids
Organoids and Tumor Immune Microenvironment: a new strategy of modelling Figure 1 – Schematic representation of ALI PDO establishment starting from human and mouse derived tumor biopsies. All those models faithfully recapitulate the TME and preserve the TCR...
da molecularpost | Giu 3, 2023 | Biologia Molecolare, Organoids
CRISPR/Cas9 mediated repair of CFTR in cystic fibrosis patient-derived intestinal organoids Figure 1 – Schematic illustration of the gene correction protocol. Stem cells are labelled in green. Created with biorender.com Abstract Single intestinal stem cells in...
da molecularpost | Mag 29, 2023 | Biologia Molecolare, Organoids
Transplantation of intestinal organoids into murine models Figure 1. Schematic illustration of procedure through which the transplantation of intestinal organoids is performed Abstract Intestinal organoids are in vitro tools that can be transplanted in vivo. They can...
da molecularpost | Mag 26, 2023 | Biologia Molecolare, Intestine, Organoids
New Culture Condition for Human Intestinal Organoids allowing Secretory Cells appearance and Self-Renewal Capacity maintenance Figure 1. Schematic comparison between IF-cultured organoids and those cultured with the p38i-medium, highlighting the IF-medium advantages....
da molecularpost | Mag 25, 2023 | Biologia Molecolare, Liver, Organoids
Genetic engineering of human fetal and adult liver organoids by CRISPR-Cas9 technology Fig. 1 – Schematic overview of this protocol (Created with BioRender.com) Abstract The liver is composed of two types of epithelial cells: hepatocytes and liver ductal cells....